Resource Room

Press releases

08.11.2020

BridgeBio Pharma Expands Reach Into China and Other Major Asian Markets Through Strategic Collaboration With Perceptive Advisors-Founded Company, LianBio

07.28.2020

Ivy Brain Tumor Center and BridgeBio Pharma’s QED Therapeutics Announce Dosing of First Patient in Investigator-Initiated Phase 0/2 Clinical Trial of Infigratinib in Recurrent Glioblastoma

07.15.2020

BridgeBio Pharma’s QED Therapeutics Doses First Child in Phase 2 Clinical Trial of the Investigational Medicine Infigratinib in Achondroplasia

05.29.2020

BridgeBio Pharma’s QED Therapeutics Presents Data on Infigratinib in Cholangiocarcinoma and Urothelial Carcinoma at the American Society of Clinical Oncology 2020 Virtual Scientific Program

05.11.2020

BridgeBio Pharma’s QED Therapeutics Announces Preclinical Data Demonstrating Potential Of Low-Dose Infigratinib In Achondroplasia

03.12.2020

BridgeBio Pharma’s QED Therapeutics Announces Dosing of First Patients in Phase 3 and Phase 2 Clinical Trials of Infigratinib in Tumors with FGFR Genetic Alterations

01.06.2020

BridgeBio Pharma’s QED Therapeutics Receives Fast Track Designation For Infigratinib In Adults With First-Line Advanced Or Metastatic Cholangiocarcinoma And Orphan Drug Designation For Infigratinib For Treatment Of Cholangiocarcinoma

10.17.2019

QED and Parent Company BridgeBio Announce Preclinical Data Supporting Tolerability and Activity of Low-dose Infigratinib in Treating Achondroplasia

09.24.2019

Ivy Brain Tumor Center and BridgeBio Subsidiary, QED Therapeutics, Announce Collaboration to Advance Cancer Research and Treatment Options

06.03.2019

QED Therapeutics Presents New Data on the Potential for Infigratinib to Treat Upper Tract Urothelial Carcinoma

04.01.2019

Preclinical Data Demonstrates the Potential of QED Therapeutics’ Infigratinib in Multiple FGFR+ Tumor Types

12.10.2018

QED Therapeutics Announces a Collaboration with Foundation Medicine to Develop Companion Diagnostics for Infigratinib

10.19.2018

QED Therapeutics Presents Data for Infigratinib in Cholangiocarcinoma in Late Breaking Abstract at the European Society of Medical Oncology 2018 Congress

08.15.2018

QED Tx – A New Company Working on a Treatment for Achondroplasia

01.30.2018

BridgeBio Pharma Licenses Late-Stage Oncology Drug Infigratinib to Tackle FGFR-Driven Maladies; Establishes New Subsidiary QED Therapeutics With $65 Million in Initial Financing

Infigratinib scientific resources

07.01.2020

Infigratinib versus gemcitabine plus cisplatin as first-line therapy in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: phase 3 PROOF trial
Abou-Alfa GK et al.

07.01.2020

Actionable targets by tumor genomic profiling in patients with cholangiocarcinoma
Francesca Avogadri, Ge Wei, Carl Dambkowski, Gary Li, Harris S. Soifer

05.29.2020

Infigratinib in advanced/unresectable or metastatic urothelial carcinoma demonstrates consistent treatment response in both first-line and later-line treatment settings
Yung Lyou et al.

05.29.2020

PROOF 302: A randomized, double-blind, placebo-controlled, phase III trial of infigratinib as adjuvant therapy in patients with invasive urothelial carcinoma harboring susceptible FGFR3 alterations
Siamak Daneshmand, Petros Grivas, Srikala S. Sridhar, Shilpa Gupta, Joaquim Bellmunt, Guru Sonpavde, Mark T. Fleming, Seth P. Lerner, Yohann Loriot, Hao Wang, Hiywot Takkele, Corina Andresen, Jessica Rearden, Stacie Shepherd, Sumanta K. Pal

05.29.2020

A retrospective analysis of post second-line chemotherapy treatment outcomes for patients with advanced or metastatic cholangiocarcinoma and FGFR2 fusions
Milind M. Javle, Saeed Sadeghi, Anthony B. El-Khoueiry, Lipika Goyal, Philip Agop Philip, Robin Kate Kelley, Ivan Borbath, Teresa Macarulla, Wei-Peng Yong, Suebpong Tanasanvimon, Amit Pande, Ai Li, Michael Howland, Stacie Shepherd, Ghassan K. Abou-Alfa

05.08.2020

Low-dose infigratinib treatment does not lead to changes in phosphorus in preclinical animal studies
Maribel Reyes, PhD, Uma Sinha, PhD, Gary Li, PhD, David Martin, PhD

05.08.2020

Prospective clinical assessment study in children with achondroplasia: the PROPEL trial
Ravi Savarirayan, Peter Kannu, Carl L. Dambkowski, Daniela Rogoff, Melita Irving

05.08.2020

FGFR-selective tyrosine kinase inhibitors, such as infigratinib, show potency and selectivity for FGFR3 at pharmacologically relevant doses for the potential treatment of achondroplasia
Katherine Dobscha, MBA, Ge Wei, PhD, Carl L Dambkowski, MD, Daniela Rogoff, MD, PhD

05.08.2020

Support for a new therapeutic approach of using a low-dose FGFR tyrosine kinase inhibitor (infigratinib) for achondroplasia
Benoit Demuynck, Justine Filpo, Gary Li, Carl Dambkowski, Laurence Legeai-Mallet

06.03.2019

Infigratinib versus gemcitabine plus cisplatin multicenter, open-label, randomized, phase 3 study in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: the PROOF trial
Javle M et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

06.03.2019

Infigratinib in upper tract urothelial carcinoma vs urothelial carcinoma of the bladder and association with comprehensive genomic profiling/cell-free DNA results
Dizman N et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

10.19.2018

A phase II study of infigratinib (BGJ398), an FGFR-selective tyrosine kinase inhibitor (TKI), in patients with previously-treated advanced cholangiocarcinoma containing FGFR2 fusions
Javle M et al. Presented at the European Society for Medical Oncology 2018 Congress; October 19-23, 2018; Munich, Germany.

05.30.2018

Efficacy of BGJ398, a fibroblast growth factor receptor 1–3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations
Pal SK et al. Published in Cancer Discovery.

04.11.2016

Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model
Komla-Ebri D et al. Published in The Journal of Clinical Investigation.

More about FGFR and FGFR-driven diseases

02.13.2019

About biliary cancer
Dana-Farber Cancer Institute website.

01.17.2018

Cholangiocarcinoma with FGFR genetic aberrations: a unique clinical phenotype
Jain A et al. Published in JCO Precision Oncology.

06.07.2017

Comprehensive genomic characterization of upper tract urothelial carcinoma
Moss TJ et al. Published in European Urology.

01.22.2015

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Sia D et al. Published in Nature Communications.

12.23.2014

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
Knowles MA, Hurst CD. Published in Nature Reviews Cancer.

04.25.2014

Second-line chemotherapy in advanced biliary cancer: a systematic review
Lamarca A et al. Published in Annals of Oncology.

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