Infigratinib scientific resources

06.03.2019

Infigratinib versus gemcitabine plus cisplatin multicenter, open-label, randomized, phase 3 study in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: the PROOF trial
Javle M et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

06.03.2019

Infigratinib in upper tract urothelial carcinoma vs urothelial carcinoma of the bladder and association with comprehensive genomic profiling/cell-free DNA results
Dizman N et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

10.19.2018

A phase II study of infigratinib (BGJ398), an FGFR-selective tyrosine kinase inhibitor (TKI), in patients with previously-treated advanced cholangiocarcinoma containing FGFR2 fusions
Javle M et al. Presented at the European Society for Medical Oncology 2018 Congress; October 19-23, 2018; Munich, Germany.

05.30.2018

Efficacy of BGJ398, a fibroblast growth factor receptor 1–3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations
Pal SK et al. Published in Cancer Discovery.

04.11.2016

Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model
Komla-Ebri D et al. Published in The Journal of Clinical Investigation.

More about FGFR and FGFR-driven diseases

02.13.2019

About biliary cancer
Dana-Farber Cancer Institute website.

01.17.2018

Cholangiocarcinoma with FGFR genetic aberrations: a unique clinical phenotype
Jain A et al. Published in JCO Precision Oncology.

06.07.2017

Comprehensive genomic characterization of upper tract urothelial carcinoma
Moss TJ et al. Published in European Urology.

01.22.2015

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Sia D et al. Published in Nature Communications.

12.23.2014

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
Knowles MA, Hurst CD. Published in Nature Reviews Cancer.

04.25.2014

Second-line chemotherapy in advanced biliary cancer: a systematic review
Lamarca A et al. Published in Annals of Oncology.

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