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Press releases

01.06.2020

BridgeBio Pharma’s QED Therapeutics Receives Fast Track Designation For Infigratinib In Adults With First-Line Advanced Or Metastatic Cholangiocarcinoma And Orphan Drug Designation For Infigratinib For Treatment Of Cholangiocarcinoma

10.17.2019

QED and Parent Company BridgeBio Announce Preclinical Data Supporting Tolerability and Activity of Low-dose Infigratinib in Treating Achondroplasia

09.24.2019

Ivy Brain Tumor Center and BridgeBio Subsidiary, QED Therapeutics, Announce Collaboration to Advance Cancer Research and Treatment Options

06.03.2019

QED Therapeutics Presents New Data on the Potential for Infigratinib to Treat Upper Tract Urothelial Carcinoma

04.01.2019

Preclinical Data Demonstrates the Potential of QED Therapeutics’ Infigratinib in Multiple FGFR+ Tumor Types

12.10.2018

QED Therapeutics Announces a Collaboration with Foundation Medicine to Develop Companion Diagnostics for Infigratinib

10.19.2018

QED Therapeutics Presents Data for Infigratinib in Cholangiocarcinoma in Late Breaking Abstract at the European Society of Medical Oncology 2018 Congress

08.15.2018

QED Tx – A New Company Working on a Treatment for Achondroplasia

01.30.2018

BridgeBio Pharma Licenses Late-Stage Oncology Drug Infigratinib to Tackle FGFR-Driven Maladies; Establishes New Subsidiary QED Therapeutics With $65 Million in Initial Financing

Links to infigratinib clinical trials

Phase 3 study of BGJ398 (oral infigratinib) in first line cholangiocarcinoma with FGFR2 gene fusions/translocations
National Institutes of Health website.

A phase II, single arm study of BGJ398 in patients with advanced cholangiocarcinoma
National Institutes of Health website.

BGJ398 in non-muscle-invasive urothelial carcinoma of the bladder
National Institutes of Health website.

BGJ398 in treating patients with FGFR positive recurrent head and neck cancer
National Institutes of Health website.

Infigratinib scientific resources

06.03.2019

Infigratinib versus gemcitabine plus cisplatin multicenter, open-label, randomized, phase 3 study in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: the PROOF trial
Javle M et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

06.03.2019

Infigratinib in upper tract urothelial carcinoma vs urothelial carcinoma of the bladder and association with comprehensive genomic profiling/cell-free DNA results
Dizman N et al. Presented at the American Society of Clinical Oncology 2019 Annual Meeting; May 31-June 4, 2019; Chicago, IL.

10.19.2018

A phase II study of infigratinib (BGJ398), an FGFR-selective tyrosine kinase inhibitor (TKI), in patients with previously-treated advanced cholangiocarcinoma containing FGFR2 fusions
Javle M et al. Presented at the European Society for Medical Oncology 2018 Congress; October 19-23, 2018; Munich, Germany.

05.30.2018

Efficacy of BGJ398, a fibroblast growth factor receptor 1–3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations
Pal SK et al. Published in Cancer Discovery.

04.11.2016

Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model
Komla-Ebri D et al. Published in The Journal of Clinical Investigation.

More about FGFR and FGFR-driven diseases

02.13.2019

About biliary cancer
Dana-Farber Cancer Institute website.

01.17.2018

Cholangiocarcinoma with FGFR genetic aberrations: a unique clinical phenotype
Jain A et al. Published in JCO Precision Oncology.

06.07.2017

Comprehensive genomic characterization of upper tract urothelial carcinoma
Moss TJ et al. Published in European Urology.

01.22.2015

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Sia D et al. Published in Nature Communications.

12.23.2014

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
Knowles MA, Hurst CD. Published in Nature Reviews Cancer.

04.25.2014

Second-line chemotherapy in advanced biliary cancer: a systematic review
Lamarca A et al. Published in Annals of Oncology.

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